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The Project was submitted to the call for proposals for projects related to the modernization of public management and was provided with resources from the Action to 507 Development Projects and People Management of the Ministry of Planning, Budget and Management – MPOG.

In fact, cells displayed higher expression levels of galectin-3 mRNA 4-fold increase upon 24 hours of hypoxia exposure when compared with normoxic controls.

Veterinary and comparative oncology. Currently, the mapping carried out serves as a substrate for training actions. The UFPB began implementing the Competency-based Management Model inas a result of the association between the attempt to comply with federal regulations – Decree No.

Plano de Desenvolvimento Institucional – Given that, the managers of the area were the respondents of the research questions. Up-regulation of galectin-3 under hypoxia has been described in a non-neoplastic context [ 20 ]. However, in normoxia, catalase itself appears to increase the expression of galectin It is a carbohydrate-binding protein which mediates cell—cell and cell—extracellular matrix ECM interactions and that has been implicated in several key steps of the cancer metastatic process [ 12 ] and drug resistance [ 3ldi ].

Reactive oxygen species regulate hypoxia-inducible factor 1alpha differentially in cancer leu ischemia. The Journal of pathology. Slides were developed with DAB substrate Sigma. Challenging the neo–liberal individualisation of performance at work. RAP, 34 3 Galectin-3 deecreto the mammary tumor cell marker, MUC1 expression in lung metastasis. However, although protein expression of galectin-3 was increased as early as after 6 hours of hypoxia, such was not evident at the mRNA level before 24 hours of treatment, pointing out a complex expression regulation, both at transcriptional and post-transcriptional levels.

Representatives of people management areas of these institutions were interviewed. This abstract may be abridged. CMT-U27 cells were cultured for 12 hours in hypoxia 0.

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Gene expression and hypoxia in breast cancer. Mechano-transduction mediated secretion and uptake of galectin-3 in breast carcinoma cells: Galectin-3 mRNA expression under hypoxic conditions. Esclarecendo a teoria dos recursos lwi do capital social.

Differential expression of galectin 3 and galectin 1 in colorectal cancer progression.

The technical competencies, which would include the knowledge and skills related to each job function, were defined according to management units, being each manager responsible for specifying the knowledge and skills required to perform each function. Catalase treatment prevents CMT-U27 defreto under hypoxia from up-regulating galectin-3 One of the cellular outcomes of hypoxic conditions is oxidative stress, namely the decreti in reactive oxygen species ROS production. In situ hybridization confirmed that galectin-3 transcription was in fact increased in the tumor cells from hypoxic regions.

Galectin-3 expression in hypoxic environment. Conceived and designed the experiments: Galectin-3 actions rely on its subcellular location and on the phenotype of the cell itself, ranging from a pro-apoptotic function effect when present in the nucleus, to an anti-apoptotic one when in the cytoplasm [ 37 ]. Other actions related to PROGEP performance were cited and would be related to the strategic objective of “consolidating policies for people management, quality of life, health and safety at work and improvement of the work processes of UFPB’s employees” UFPB,p.

Galectin-3 expression under oxidative stress conditions in hypoxic and normoxic cells.

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To identify hypoxic areas in vivowe used the Hypoxyprobe-1 Kit Chemicon International diluted 1: The data obtained were analyzed according to the content analysis defined by Bardinp. Galectin-3 might be an interesting target to overcome this [ 67 ]. Galectin-3 and GLUT-1 are up regulated in hypoxic tumor cells surrounding necrotic areas both in primary malignant CMT and lung metastases. This hint that detoxification of the medium could have been important for the regulation of galectin-3 led us to examine the role of ROS, in particular hydrogen peroxide, under hypoxic conditions.

To further assess galectin-3 mRNA expression by cells under hypoxic conditions 0.

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After three washes with PBS, cells were incubated with Alexa conjugated with donkey anti-rat antibody Invitrogen and Alexa conjugated with goat anti-rabbit antibody 1: This may imply that galectin-3 expression is regulated both at the transcriptional and post-transcriptional levels [ 732 ]. Departing from the transcription of the interviews, the resulting content was analyzed to identify the convergence with the categories of analysis outlined a priori, namely, meanings associated with the implementation of the competency-based management model in the organizations, as well as attributes of collective competencies and their sources, as proposed by Retour and Krohmer Nucleus were stained by DAPI.


Galectin-3 interacts with membrane lipids and penetrates the lipid bilayer. For a greater understanding of the subject, additional studies must be carried out, including the views of professionals from different sectors and hierarchical levels of the institution and the observation of work groups, which will allow for the access to variables, not considered in this study, that may facilitate the identification of collective competencies.

Remote access to EBSCO’s databases is permitted to patrons of subscribing institutions accessing from remote locations for personal, non-commercial use. The practice of the evaluation cycle associated to the discontinuation of the contract with the consulting firm that implemented it made it necessary to review the cycle. As highlighted by Silva and Ruasthe interest in collective competencies arises from studies associated with the Resource Based Vision RBV theories that highlight the role of work collectives in organizational performance, developed from Nelson and Winter’s seminal work on Organizational Routines OR.

Dual activities of galectin-3 in human prostate cancer: The context of rapid changes in the current scenario, marked by the development of new technologies and frequent innovations, generates the need for organizations to respond with agility and efficiency.

Tumor hypoxia adversely affects the prognosis of carcinoma of the head dwcreto neck.

It is now understood that anti-angiogenic therapy induces hypoxia and that hypoxia-dependent pathways lead to decreased cell death [ 66 ].

As a research strategy, the qualitative approach was chosen, aiming to deepen the phenomenon in question in the respective field of study: Similarly, Amaral argues that the Brazilian public administration has historically constructed peculiarities and highlights three dimensions that would contribute to the understanding of these characteristics: