Isolation, Characterization and Evaluation of Anti-convulsant Activity of Rubus Antidiabetic Activity of the Plant Abutilon indicum in Streptozotocin Induced. Abutilon hirtum extract and fractions exhibited anti-inflammatory analgesic, antipyretic and antipyretic activities which may be attributed by the. Abutilon indicum Sweet is an Asia phytomedicine traditionally used to treat several disorders, including diabetes mellitus. However, molecular.

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According to many scientific reports, the leaf extracts possess hypoglycemic, hepatoprotective, antibacterial and larvicidal properties [ 10131516 ]. The animals were weighed on day 0, 4, 7, 11 and 14 for corrected doses of medication.

However, prior to treatment administration day 0basal plasma glucose concentration did not significantly differ between groups.

Enter your contact information below to receive full paper. View at Google Scholar M. Since troglitazone TGZ was voluntarily withdrawn from activty market in March due to occurrence of severe idiosyncratic liver injury, it is necessary to establish a safer compound that shows antidiabetic activity.

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Anti-diabetic and analgesic activity of leaves of abutilon indicum

Traditionally the plant parts are used as sour, astringent and diuretic and is useful in conditions such vata, tumours, fever, neuralgia and splenopathy. The results revealed that the leaves contain steroids, sapogenins, carbohydrates and flavonoids.

This medicinal plant plays an important role in folk medicine; in Thailand, it has been used as a blood tonic, carminative, antipyretic, anti-cough, diuretic, anti-inflammatory, laxative and antidiabetic [ 12 ], whereas in India and China, it has been used for urinary disease, gonorrhea, jaundice, rheumatism, high fever, mumps, pulmonary tuberculosis, activitty, lack of urination and some nervous and ear problems [ 1314 ].

Dhirender Kaushik, Ajay Kumar, A. Sweet is an Asian phytomedicine traditionally used to treat several disorders, including diabetes mellitus.

The defective glucose transport system may play an important role in the pathogenesis of peripheral insulin resistance, and glucose uptake in target tissues is a critical step in maintaining glucose homeostasis and in clearing the postprandial glucose load [ 45 ].


This pathway has been reported to be involved in the regulation of GLUT 1 expression [ 47 ]. The STZ-induced diabetic rats were randomly allocated into four groups 6—9 rats per group A.

activitty These results suggest that the extract from A. Results from other researchers have shown that this plant also contains saponins and glycosides [ 10 ]. Pinus roxburgii sarg is one of the species belonging to family pinaceae found in East Asia-Himalayas from Acttivity to Bhutan, forms extensive forests to meters and does best on north slopes on good soils. The effect of butanol fraction of A. The alkaloid berberine has also been reported to activate GLUT1-mediated glucose uptake [ abutolon ].

Insulin resistance is a key feature in type 2 DM as well as in obesity and plays an important pathophysiological role [ 3 ]. The pGL3-Basic vector empty was used as a negative control, and pGL3-control vector was used for a positive control.

Looking for Past Issues? Issue, Vol 19, Issue 4, Vol 19, Nov. A number of medicinal uses has been qntidiabetic some important onces are Antioxidant, antihelmintic activity, Hepato-Protective activity, antidiarrhoeal activity, Tumor growth inhibitory activity. Diabetes mellitus DM is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both; the incidence of diabetes is increasing worldwide.

Subsequently, we examined the effect of the extract on transcription activation of GLUT1.

Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

These results demonstrated that the chloroform fraction has significant antidiabetic activity and there is need to isolate the active compounds and qbutilon them as a potential antidiabetic compound Download Full Text PDF.

A similar significant decrease was also observed in rats treated with glibenclamide. To examine whether A.

Evidence-Based Complementary and Alternative Medicine. The thorax was opened, and the diaphragm was removed. The findings of antidiabetic abuitlon in this study are summarized in Figure 7and support the ethnobotanical use of A.


Pharmacognostical Evaluation of Tylophora indica Burm. A yield of turpentine from resin averaged was almost The animals were fed with free access to a commercial pellet diet C. View at Google Scholar S. Clayton, Medical Plants in Thailandvol.

Interestingly, the mRNA antidiabetiv of adiponectin in the butanol fraction-treated group was higher than the control throughout the differentiation. Standardization problems arise from the complex composition of drugs which are used in the form of whole plant, parts of the plants and of plant extract.

It is used internally as well as externally for many diseases. Originally, TZDs were identified based on their antihyperglycemic activity, but they are also able to improve other abnormalities associated with type 2 diabetes, such as hyperlipidemia, atherosclerosis, hypertension, chronic inflammation and fibrinolytic state. Click here to get them!! The oil is also an ingradient in many ointments, liniments and lotions for treating minor aches and pains as well as antidianetic, when applied externally.

Thus, these results provide evidence that these compounds may lead to affect the antidiabetic activity of A. Another pathway that has been implicated in glucose transport, not by translocation of GLUT, but by activation of GLUT, is the p38 pathway [ 46 ], which is also interesting for further study.

Volume2,Issue2 – Pharmacognosy Phytochemistry

Sweet is an erect, branched shrub of 0. The present study deals with the micro morphological studies carried out on the leaves of Cayratia carnosa, one of the World Health Organization WHO accepted parameter for identification of medicinal plants. Tress is extensively tapped for their resin in India and is the main source of resin in that region. The methanolic extract was subjected to anticonvulsant activity by MES induced epilepsy and determination of neurotransmitter concentrations in rat brain after induction of epilepsy.