Owing to pseudoexfoliation glaucoma’s prevalence and severity, gonioscopy should be performed to assess for pigment deposition and a Sampaolesi’s line. Sampaolesi line is a sign which may be observed during a clinical eye examination. During gonioscopy if an abundance of brown pigment is seen at or anterior. The Glaucomas. Volume II – Open Angle Glaucoma and Angle Closure Glaucoma. Authors; (view affiliations). Roberto Sampaolesi; Juan Roberto Sampaolesi.

Author: Gardalkis Faerg
Country: Saint Kitts and Nevis
Language: English (Spanish)
Genre: Sex
Published (Last): 2 December 2014
Pages: 54
PDF File Size: 2.60 Mb
ePub File Size: 8.44 Mb
ISBN: 612-8-21990-291-2
Downloads: 80163
Price: Free* [*Free Regsitration Required]
Uploader: Keramar

Because the pressure rise OS was gradual, patients may not experience pain and severe cornea edema that is seen with sudden angle closure glaucoma. The deposition of this material in the trabecular meshwork can result in aqueous outflow obstruction, raised intraocular pressure IOP and glaucoma. Original article contributed by: Pseudoexfoliative syndrome PXF is a systemic condition characterized by the deposition of a protein-like material within the anterior segment flaucoma the eye, most notably on sampaoles anterior lens capsule, and other organs.

Retrieved from ” http: Cyclodestruction of the ciliary body last resort.

Pseudoexfoliation Glaucoma:

The confidence interval of the normal growth curve allows the prediction of the maximum normal axial length for any given age. Clinical examination using biomicroscopy has 85 percent sensitivity and percent specificity. Other evidence of narrow angle includes Iris bombe configuration,posterior synechiae, and vossius ring on the lens capsule. Challa is assistant professor of ophthalmology on the glaucoma service and residency director at the Duke University Eye Center in Durham, N.

Miotic drops may exacerbate angle closure secondary to PXF. Glaucoma Today gpaucoma mailed bimonthly six times a year to 11, glaucoma specialists, general ophthalmologists, and clinical optometrists who treat patients with glaucoma. This brief review will discuss the pathophysiology, clinical course and signs, differential diagnosis, and treatment strategies of this disease.


Patients with uncontrolled glaucoma are poor candidates for laser iridotomy, since clearing of the meshwork and the subsequent IOP reduction requires a long time after the laser iridotomy.

Histochemically, pseudoexfoliative material is glycoconjugates surrounding a protein core. He saw an eye doctor and was glauccoma with angle closure glaucoma. Create a personal account to register for email alerts with links to free full-text articles.

Ophthalmology and Visual Sciences. Privacy policy About EyeWiki Disclaimers. Many pedigrees have been published that demonstrate an autosomal dominant inheritance. Of note, once laser trabeculoplasty starts to wear off, patients with pseudoexfoliation glaucoma tend to demonstrate a more rapid IOP sampaolesl than POAG patients.

In pigment dispersion syndrome and pigmentary glaucoma, the iris insertion is typically posterior, and the peripheral iris configuration tends to be concave.

Gonioscopy most commonly reveals an open anterior chamber drainage angle. Future Directions Current research on pseudoexfoliation syndrome is centered on genetic factors that predispose certain populations to its glaudoma.

Purchase access Subscribe to the journal. Decreasing pupillary movement may reduce iridolenticular friction and thus avert the liberation of iris pigment, slow the progression of trabecular blockage, and perhaps allow the meshwork to clear.

The melanin dispersion is from atrophy of the iris pigment epithelium. It is important to distinguish these conditions, as PXF glaucoma may need to be followed more closely and treated more aggressively as it is known to progress more rapidly. Pseudoexfoliation glaucoma tends to follow an unpredictable course, as it can be relatively benign or progress rapidly to advanced optic nerve damage. Workup A thorough history may reveal a family history of pseudoexfoliation syndrome.


Not reviewed add Contributing Editors: Theoretically, miotics should be the first line of treatment. Liberation of iris pigment in the anterior chamber. Due to the volatile nature of this condition, patients with pseudoexfoliation glaucoma who demonstrate rising IOP should be examined every one to three months.

Sign in to make a comment Sign in to your personal account. Purchase access Subscribe now.

Sampaolesi line – Wikipedia

Decreased pupillary dilation, along with weakened zonular fibers and synechiae between the iris and peripheral anterior lens capsule, make the cataract surgery technically difficult. Urology Rx Linked to Maculopathy Feature: Glauckma lysyl oxidase-like protein 1 LOXL1 gene is important for elastin metabolism. Web Privacy Policy Nondiscrimination Statement. Pseudoexfoliation of the lens capsule. Patients with pseudoexfoliation syndrome and no evidence of glaucoma are generally not treated, but they should be followed every six to 12 months as they have an increased risk of developing glaucoma.

Traditional IOP-lowering medications are less effective in pseudoexfoliation glaucoma than in POAG, but they are used frequently as first-line therapy. Laser trabeculoplasty has been reported to be particularly effective in PXF glaucoma, due to the relatively pigmented angles. This same material is also deposited in other parts of the body, e.